Justeen Pharmaceauticals Limited

Tesa 50

Justeen

Tesa 50

TESA

Diclofenac Potassium Tablets 50mg

  • COMPOSITION

    Each film coated tablet contains:
    Diclofenac Potassium BP: 50mg
    Excipiants: q.s.

    It is a non-steroidal anti-inflammatory drug. It has analgesic antipyretic and anti-inflammatory actions.

  • Mode of Action

    Diclofenac is an inhibitor of cyclooxygenase. It also appears to reduce intracellular concentrations of free arachidonate in leukocytes. Its potency is greater than indomethacin, naproxen etc.

  • Pharmacokinetics

    After oral administration it is rapidly and completely absorbed. It shows substantial first pass effect and is highly protein bound. It is metabolised, excreted in urine and bile.

    Onset of action: Analgesic effect 1 hour, antirheumatic effect about 2 weeks.

    Duration of action: Up to 12hours

  • Adverse Effects

    Nausea, vomiting, epigastric discomfort, skin rash, peptic ulcer, fluid retention, oedema, impairment of hepatic function rarely.

  • Contra Indications

    GI bleeding, active peptic ulcer, NSAID induced allergic asthma.

  • Special Precautions

    Impairment of hepatic, renal or cardiac function.

    Children, blood coagulation disorders.
    Recent proctitis.
    GI disorders.

    In Pregnancy: Contraindicated in the last trimester.

    In Lactations: Use with caution.

    In Elderly Patients: May be given in reduced dose.

  • Interactions

    • Lithium & Digoxin: Blood levels of lithium and digoxin increased leading to enhanced efficacy and possible toxicity.
    • Diuretics: Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.
    • Methotrexate: Toxicity enhanced.
    • Salicylates: Efficacy of salicylates reduced.
    • Cyclosporine: Increases nephrotoxicity of both agents.
    • Hydantoins: Increases serum levels resulting in toxicity.

  • Indications

    Management of pain and primary dysmenorrhoea when prompt pain relief is desired.

  • Dosage

    Starting dose 50mg tid. In some patients an initial dose of 100mg followed by 50mg doses provide better relief.

  • STORAGE

    Store in a cool, dry & dark place.
    KEEP MEDICINES OUT OF REACH OF CHILDREN.

  • PRESENTATION

    Pack of 10 blister strips of 10 tablets each.