Justeen Pharmaceauticals Limited

Tavclox

Justeen

Tavclox

TAVCLOX-500 CAPSULE

Tavclox-500 Capsules

  • Composition

    Each Capsule Contains:
    Ampicillin Trihydrate equivalent to Ampicillin 250mg
    Cloxacillin Sodium equivalent to Cloxacillin 250mg

  • INDICATIONS

    The use of this antibiotic may lead to the appearance of resistant strains of organisms and sensitivity testing should, therefore, be carried out wherever possible, to ensure the appropriateness of the therapy.

    Infections caused by susceptible organisms where a mixed infection is present and includes penicillin-resistant staphylococci.

  • CONTRA-INDICATIONS

    Known allergy to penicillin or cephalosporins. Cases of cross sensitivity have been reported. Babies born of hypersensitive mothers in the neonatal period.

    The oral dosage forms are not recommended for chronic, severe, or deep-seated infections such as subacute bacterial endocarditis, meningitis or syphilis. Ampicillin & Cloxacillin capsules should not he administered by sub-conjunctival injection or used as an eye drop as it contains cloxacillin.

  • DOSAGE AND DIRECTIONS FOR USE

    The average adult dose for Ampicillin & Cloxacillin capsules is 2 - 4g per day. In severe infections, dosages may be safely increased.

    ORAL:
    Adults and children over 10 : 500 mg - Ig (I -2 x 500 mg capsules) every 6 hours.
    Children 2 -10 years : 250 -500 mg every 6 hours.
    Children up to 2 years : 250 mg every 6 hours.
    Neonates : 90 mg every 4 hours.

    NOTE: Best results are obtained if dosages are administered half to one hour prior to meals or at least two hours after meals.

  • SIDE-EFFECTS AND SPECIAL PRECAUTIONS

    Ampicillin & Cloxacillin may produce diarrhoea, nausea and heartburn. Allergic reactions which may include exfoliative dermatitis, other skin rashes, interstitial nephritis and vasculitis may occur. In this event, withdrawal of Ampicillin & Cloxacillin capsules and administration of an antihistamine will suffice in most cases. Should a serious anaphylactic reaction occur, Ampicillin & Cloxacillin capsules should be discontinued and the patient treated with the usual agents (adrenalin, corticosteroids or antihistamines).

    A generalised sensitivity reaction with urticaria, fever, joint pains and eosinophilia can develop within a few hours to several weeks after starting treatment.

    Super infections by resistant species, such as Pseudomonas or Candida, which do not respond to penicillin therapy may occur. A sore mouth or tongue and a black hairy tongue have been reported.

    Increase in liver enzyme values have been reported. Care should be taken when high doses are given to patients with renal impairment (because of the risk of neurotoxicity) or congestive heart failure. Renal and haematological systems should be monitored during prolonged and high dose therapy. Care should be taken when treating patients with syphilis, as the larisch-Herxheimer reaction may occur shortly after starting treatment.

    This reaction, manifesting as fever, chills, headache and reactions at the site of the lesion, can be dangerous in cardiovascular syphilis or where there is a serious risk of increased local damage such as with optic atrophy.

    Haemolytic anaemia and leucopenia, prolongation of bleeding time and detective platelet function have been observed usually following high intravenous doses. Convulsions and other signs of toxicity to the CNS may occur particularly with intravenous administration or in patients with renal failure.

    Intrathecal administration of penicillins is not recommended, because it is a potent convulsant when given by this route. Ampicillin & Cloxacillin capsules contains ampicillin and should preferably not be given to patients with infectious mononucleosis, lymphatic leukaemia and patients receiving allopurinol treatment because of an increased risk of developing skin rashes. Ampicillin & Cloxacillin capsules may decrease the efficacy of oestrogen-containing oral contraceptives.

    Ampicillin & Cloxacillin capsules contains cloxacillin sodium, therefore disturbances of blood electrolytes may follow the administration of large doses.

  • IDENTIFICATION

    Ampicillin & Cloxacillin capsules:
    Amethyst/black capsules overprinted "Ampicillin &-cloxacillin Capsules 500mg".

  • PRESENTATION

    Ampicillin & Cloxacillin Capsules 500mg:
    Foilding boxes with 10 blisters containing 10 capsules

  • STORAGE INSTRUCTIONS

    Containers of Ampicillin & Cloxacillin Capsules 500mg should be kept tightly closed in a cool (below 25?C), dry place.

    Keep medicines out of reach of children, store in a cool & dry place.